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Science of The Total Environment
2018-3-23 閱讀(624)
Science of The Total Environment
Volumes 622–623, 1 May 2018, Pages 214-221
Developmental and metabolic responses of zebrafish (Danio rerio) embryos and
larvae to short-chain chlorinated paraffins (SCCPs) exposure
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panelXiaoqianRenabHaijunZhangaNingboGengaLiguoXingcYuZhaocFeidiWangabJipingChe
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Highlights
•
Effects of SCCPs on development and metabolism of zebrafish were evaluated.
•
SCCPs were highly toxic to zebrafish larvae, with 13-day LC50 value of 34.4
μg/L.
•
Low-dose SCCPs slightly disturbed the overall metabolism in zebrafish embryos.
•
SCCPs mainly disturbed metabolisms of glycerophospholipids, fatty acids and
purine.
Abstract
Short-chain chlorinated paraffins (SCCPs) are highly toxic to aquatic
organisms, but their toxicity is yet not well characterized. In this study,
the developmental toxicity of SCCPs to zebrafish embryos/larvae was evaluated,
and a metabolomics approach was adopted to explore the impact of SCCPs
exposure on the metabolism in zebrafish embryos. Exposure to SCCPs at
concentrations of 1–200 μg/L did not produce an observable effect on the
hatching rate and morphological deformities of zebrafish embryos/larvae.
However, the survival rate of zebrafish larvae in SCCPs exposure groups
decreased in a concentration-dependent manner. The 13-day 50% lethal
concentration (LC50) value of SCCPs was calculated to be 34.4 μg/L. Exposure
to SCCPs induced a significant change of overall metabolism, even at
environmentally relevant concentrations (1–5 μg/L). The most relevant
pathways affected by SCCPs exposure were glycerophospholipid metabolism, fatty
acid metabolism and purine metabolism. Exposure to SCCPs at concentrations of
1–5 μg/L had begun to accelerate the β-oxidation of unsaturated fatty acids
and very long chain fatty acids, and affect the transformation of guanine to
xanthine in the pathway of purine metabolism. Furthermore, when the exposure
concentrations of SCCPs were increased to 50–200 μg/L, the levels of
phospholipids and amino acids were significantly raised; whereas the levels of
fatty acids, carnitines and inosine were significantly decreased. In view of
the significant effect on metabolism, the sub-chronic and chronic toxicity of
SCCPs to fish should be concerned.
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Keywords
Short-chain chlorinated paraffinsZebrafish
embryo/larvaeMetabolomicsDevelopmental toxicity
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