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Rabbit Anti-eNOS 抗體,現(xiàn)貨ing
From:abcam
Catalog Number : RS-0163R
Quantity size : 50ul (dilute with pH 7.4 0.01 M PBS or antibody diluent )
background:
Nitric oxide synthase NOS oxidizes a guanidine nitrogen of arginine releasing nitric oxide in the form of a free radical and citrulline. Nitric oxide thus generated acts as a messenger in diverse functions including vasodilation neurotransmission, anti tumor and anti pathogenic activities. NOS is classified under three types: neuronal NOS (nNOS) or brain NOS (bNOS); inducible NOS (iNOS) or macrophage NOS (mNOS); and endothelial NOS (eNOS).
eNOS is a calcium/calmodulin dependent enzyme which undergoes several post translational modifications, including acylation with myristate and palmitate, and phosphorylation on numerous residues. As with the other members of the NOS family, eNOS derives the diffusible multifunctional second messenger NO from L arginine through a series of reactions in which L citrulline is an intermediate. eNOS plays an important role in controlling vascular tone, plaet aggregation, and cardiac myocyte function..
Function:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-Anti-eNOS 抗體,現(xiàn)貨inginduced angiogenesis in coronary vessels and promotes blood clotting through the activation of plaets.
Isoform e3C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
Specificity : Anti- eNOS is a Rabbit Polyclonal antibody
specific for anti-Anti-eNOS 抗體,現(xiàn)貨ing eNOS of Human, Mouse, Rat, Dog, Pig, Cow, Sheep, Guinea Pig
- use for western blotting,elisa,immunoprecipitation and immunohistochemistry
Application :
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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