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GHBP Bovine/ 重組牛生長激素結(jié)合蛋白產(chǎn)品編號：CYT-471

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GHBP Bovine/ 重組牛生長激素結(jié)合蛋白產(chǎn)品編號：CYT-471
產(chǎn)品規(guī)格：100μg/200μg/1mg

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GHBP Bovine/ 重組牛生長激素結(jié)合蛋白

產(chǎn)品編號：CYT-471
產(chǎn)品規(guī)格：100μg/200μg/1mg

Synonyms	GHR, GHBP, GH receptor, Somatotropin receptor.
Introduction	GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome （GHIS）, a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein （GHRtr）, have been observed but have not been thoroughly characterized.
Description	Growth Hormone Binding Protein Bovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28 kDa. GHBP Bovine is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered White lyophilized （freeze-dried） powder.
Formulation	The Growth Hormone Binding Protein Bovine was lyophilized from a concentrated （1mg/ml） solution with 0.0045mM NaHCO3.
Solubility	It is recommended to reconstitute the lyophilized GHBP Bovine in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Stability	Lyophilized Growth Hormone Binding Protein Bovine although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GHBP Bovine should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
Purity	Greater than 95.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE.
Amino acid sequence	The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Phe-Ser-Gly-Ser.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.