Anti-RANK抗體,核轉(zhuǎn)錄因子NF-κB受體/核因子kB受體活化因子抗體
英文介紹:CD265 is a member of the tumor necrosis factor receptor (TNFR) family. Human and murine CD265 share 81% amino acid identity in their extracellular domains. CD265 is widely expressed, with highest levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. CD265 is also expressed in dendritic cells. RANK and RANK ligand (RANKL) are important regulators of interactions between T cells and dendritic cells. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of CD265. TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for CD265. The biological functions mediated by RANK include activation of NFkappaB and cjun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis. The soluble form of CD265 is able to block TRANCE induced biological activity. The binding of anti-CD265 to cell surface CD265 triggers signal transduction and induces CD265 mediated bioactivity.
此產(chǎn)品本公司有標記的一抗出售,相關(guān)標記有:Alexa Fluor 350 標記、Alexa Fluor 488 標記、Alexa Fluor 555 標記、Alexa Fluor 647 標記、AP標記、APC標記、Biotin標記、Cy3標記、Cy5標記、Cy5.5標記、Cy7標記、FITC標記、Gold標記、HRP標記、PE標記、PE-Cy3標記、PE-CY5標記、PE-CY5.5標記、PE-CY7標記、RBITC標記
注意事項:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品名稱:Anti-RANK抗體,核轉(zhuǎn)錄因子NF-κB受體/核因子kB受體活化因子抗體
產(chǎn)品編號:BYK-7343R
英文名稱:Anti-RANK
中文名稱:核轉(zhuǎn)錄因子NF-κB受體/核因子kB受體活化因子抗體
英文別名:TNFRSF11A; CD 265; CD265; CD265 antigen; Activator of NFKB; EOF; FEO; mRANK; NFKB activator; ODFR; OFE; Osteoclast differentiation factor receptor; PDB 2; Receptor activator of NF KB; receptor activator of nuclear factor kappa B; TNFRSF 11A; TNFSF11; TRANCE R; RANK receptor; TNR11_HUMAN.
產(chǎn)品規(guī)格:0.1ml/0.2ml
此抗體本公司有單抗和多抗,可用于免疫組化(IHC),免疫印跡(WB),酶聯(lián)免疫(ELISA),IF、IP、流式細胞術(shù)等實驗(可來電索取說明)
保存條件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-RANK抗體,核轉(zhuǎn)錄因子NF-κB受體/核因子kB受體活化因子抗體蛋白檢測(Detection of proteins):
參考相關(guān)說明書,使用BeyoECL, Western 熒光檢測試劑等ECL類試劑來檢測蛋白。
洗片時可以使用X光片自動洗片機。如果沒有自動洗片機,可以用顯影定影試劑盒自行配制顯影液和定影液進行手工洗片。
膜的重復(fù)利用(Membrane recovery)
如果蛋白樣品非常寶貴,可以使用Western一抗二抗去除液處理蛋白膜,以重復(fù)利用蛋白膜。
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