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Anti-BRCA1/FITC,FITC標(biāo)記的BRCA1抗體

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研盟生物標(biāo)記抗體“Anti-BRCA1/FITC,FITC標(biāo)記的BRCA1抗體"，規(guī)格100ul，保證品質(zhì)，咨詢：

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產(chǎn)品名稱：Anti-BRCA1/FITC,FITC標(biāo)記的BRCA1抗體

產(chǎn)品編號：BYK-0802R-FITC

英文名稱 Anti-BRCA1/FITC

中文名稱 FITC標(biāo)記的乳xian癌易感基因1抗體

別名 BRCA 1; BRCA1; BRCA1/BRCA2 containing complex subunit 1; BRCA1/BRCA2-containing complex, subunit 1; BRCA1_HUMAN; BRCAI; BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast and ovarian cancer susceptibility protein 1; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; RNF53; BAP1.

研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  表觀遺傳學(xué)
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,
產(chǎn)品應(yīng)用 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量 208kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免疫原 KLH conjugated synthetic peptide derived from human BRCA1

亞型 IgG
純化方法 affinity purified by Protein A
儲存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-BRCA1/FITC,FITC標(biāo)記的BRCA1抗體產(chǎn)品介紹：This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximay 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

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