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研盟生物標記抗體“Anti-CDK1/FITC,FITC標記的周期素依賴性激酶1抗體“，規(guī)格100ul，保證品質(zhì)，咨詢：

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產(chǎn)品名稱：Anti-CDK1/FITC,FITC標記的周期素依賴性激酶1抗體

產(chǎn)品編號：BYK-0542R-FITC

英文名稱 Anti-CDK1/FITC

中文名稱 FITC標記的周期素依賴性激酶1抗體

別名 Cdc 2; Cdc2; CDK 1; CDK1; Cell division control protein 2; Cell division control protein 2 homolog; PSTAIR; Cell division cycle 2 G1 to S and G2 to M; Cell Divsion Cycle 2 Protein; Cyclin Dependent Kinase 1; DKFZp686L20222; MGC111195; p34 Cdk1; p34 Protein Kinase.

研究領域腫瘤  細胞生物  信號轉(zhuǎn)導  細胞周期蛋白  激酶和磷酸酶
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Bovine,
產(chǎn)品應用 Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量 34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免疫原 KLH conjugated synthetic peptide derived from human CDK1 C-terminus

亞型 IgG
純化方法 affinity purified by Protein A
儲存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-CDK1/FITC,FITC標記的周期素依賴性激酶1抗體產(chǎn)品介紹：The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

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