污水處理設(shè)備 污泥處理設(shè)備 水處理過濾器 軟化水設(shè)備/除鹽設(shè)備 純凈水設(shè)備 消毒設(shè)備|加藥設(shè)備 供水/儲水/集水/排水/輔助 水處理膜 過濾器濾芯 水處理濾料 水處理劑 水處理填料 其它水處理設(shè)備
上海研盟生物科技有限公司
會員1.png)
上海研盟生物科技有限公司
| 參 考 價(jià) | 面議 |
產(chǎn)品型號
品 牌
廠商性質(zhì)生產(chǎn)商
所 在 地上海市
聯(lián)系方式：辛妍查看聯(lián)系方式
更新時間：2017-10-24 09:27:23瀏覽次數(shù)：226次
聯(lián)系我時，請告知來自 環(huán)保在線研盟生物標(biāo)記抗體“Anti-IDE/FITC,FITC標(biāo)記的胰島素降解酶抗體“，規(guī)格100ul，保證品質(zhì)，咨詢：
【友情提示】：產(chǎn)品價(jià)格與說明書請?zhí)砑?，索要說明書；或者！
產(chǎn)品名稱 Anti-IDE/FITC,FITC標(biāo)記的胰島素降解酶抗體
產(chǎn)品編號 BYK-0018M-FITC
英文名稱 Anti-IDE/FITC
中文名稱 FITC標(biāo)記的胰島素降解酶抗體
別 名 BC2; Insulin degrading enzyme; FLJ35968; insulin protease; insulinase; insulysin; Abeta-degrading protease; FLJ35968; Ide; IDE_HUMAN; Insulin-degrading enzyme; OTTHUMP00000020097.
研究領(lǐng)域 腫瘤 心血管 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 生長因子和激素 糖尿病 內(nèi)分泌病 Alzheimer's
抗體來源 Mouse
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Pig, Cow,
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 117kDa
細(xì)胞定位 細(xì)胞膜
性 狀 Lyophilized or Liquid
濃 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IDE
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-IDE/FITC,FITC標(biāo)記的胰島素降解酶抗體產(chǎn)品介紹：Insulysin was identified nearly a century ago as an enzyme responsible for the degradation of insulin in cells, although the precise interactions between insulin and insulysin remain elusive. Human insulysin was cloned in 1988, and shown to be a 118 kDa protein that exists primarily as a homodimer, and perhaps also complexed with other molecules. The sequence is well conserved between humans, rats and mice, and the antibody recognizes these species. Insulysin is a metalloproteinase of the clan ME, family M16, which contains an active site HxxEH, a reversal of the canonical HExxH zinc binding motif. Considered a zinc metalloproteinase, the activity of insulysin can be blocked with EDTA or 1-10 phenanthroline. In addition to the active metalloproteinase domain, insulysin contains a second metalloproteinase site which is considered catalytically inactive, and is thought to assist in substrate binding. Insulysin is most closely related to the bacterial proteinase pitrilysin, (the human orthologue of which appears to be MPRP1) and the mammalian proteinsae nardilysin. Generally thought to be a cytoplasmic protein, insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B chain, glucagon, denatured hemoglobin, alpha amyloid protein, TGF alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer’s disease research. The pH optimum for insulysin is basic, pH 8.5, which also distinguishes it from other metalloproteinases.
Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma secretase cleaved APP that may function in nuclear signaling.
相關(guān)產(chǎn)品：
HBeAg( HBeAg Mouse Monoclonal Antibody)(1) 小鼠抗乙肝e抗原抗體（1）
HBeAg(Mouse human HbeAg Monoclonal Antibody)(2) 小鼠抗乙肝e抗原抗體（2）
VWCE/URG11(von Willebrand factor C and EGF domain-containing) 乙型肝炎病毒X蛋白(HBxAg)抗體
URGCP/URG4(Up-regulator of cell proliferation)N terminal 乙型肝炎病毒X蛋白(HBxAg)抗體N端
URGCP/URG4(Up-regulator of cell proliferation)C terminal 乙型肝炎病毒X蛋白(HBxAg)抗體C端
HBV/pre S1/S2 protein 抗乙肝病毒pre S1/乙肝病毒pre S2抗體
β-HCG(Mouse Human Chorionic Gonadotropin β Monoclonal Antibody） 小鼠抗β 亞基絨毛膜*單抗
β-HCG(Human Chorionic Gonadotropin β） mouse monoclonal antibody 小鼠抗β亞基絨毛膜*單抗
BRI3BP/HCCR-1(BRI3 binding protein) 宮頸ai基因/bri3結(jié)合蛋白抗體
α -HCG(Mouse Human Chorionic Gonadotropin α Monoclonal Antibody） 小鼠抗α 亞基絨毛膜*單抗
β-HCG (Human chorionic gonadotropin β ) 抗β亞基絨毛膜*抗體
α-HCG (Human chorionic gonadotropin α ) 抗α亞基絨毛膜*抗體
Hck(hemopoietic cell kinase) 造血細(xì)胞激酶抗體
HCFHrp/BTA(Bladdertumor antigen)human 膀胱腫瘤抗原抗體
HCN4(YMperpolarization activated Cyclic Nucleotide-gated channel 4) 環(huán)化核苷酸調(diào)控陽離子通道蛋白亞型4
HCV-Core 丙型肝炎病毒-C區(qū)抗體
HCV-HCBP1/ACY-3(Hepatitis C virus core-binding protein 1) 丙型肝炎病毒核心蛋白結(jié)合蛋白-1抗體
HCV-NS1 丙型肝炎病毒-NS1抗體
HCV-NS3 丙型肝炎病毒-NS3抗體
HCV-NS4a 丙型肝炎病毒-NS4a抗體
CD36L1/SRB1(Scavenger Receptor Class B Type 1) 高密度脂蛋白受體/清道夫受體抗體
Heamachrome 血紅素抗體
c-erbB2(HER2 receptor) 抗HER2受體抗體
HER2 receptor(erbB-2 isoform 2) 抗c-erbB-2受體抗體
HER2 receptor(NT)(erbB-2 isoform 2 receptor N-Terminus) 抗c-erbB-2受體抗體(N端)
HER2 receptor(NT)(erbB-2 isoform 2 receptor N-Terminus) 抗c-erbB-2受體抗體(N端)
HEV 戊型肝炎病毒抗體
HGF(hepatocyte growth factor) 肝細(xì)胞生長因子抗體
HGV（Hepatitis G vivus） 庚型肝炎病毒抗體
ZEBRA/HHV4/EBV（Human herpesvirus 4 type 2/epstein-barr virus ） 類皰疹病毒4抗體
HHV8/ORF K2(Human herpesvirus 8) 類皰疹病毒8抗體
HHV8/ORF K2(Human herpesvirus 8) 類皰疹病毒8抗體
您感興趣的產(chǎn)品PRODUCTS YOU ARE INTERESTED IN
環(huán)保在線 設(shè)計(jì)制作，未經(jīng)允許翻錄必究 .? ? ?
請輸入賬號
請輸入密碼
請輸驗(yàn)證碼
