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產(chǎn)品名稱 Anti-IL-2R gamma/FITC,FITC標(biāo)記的白介素2受體γ鏈抗體
產(chǎn)品編號(hào) BYK-2545R-FITC
英文名稱 Anti-IL-2R gamma/FITC
中文名稱 FITC標(biāo)記的白介素2受體γ鏈抗體
別 名 IL2 Receptor gamma; IL2R gamma; IL 2R gamma; IL-2R gamma; IL-2 receptor gamma precursor; IL2 Receptor gamma; CD132; CD 132; common cytokine receptor gamma chain; Gamma C; gamma(c); IL-2R gamma chain; IL2RG; IMD4; interleukin 2 receptor, gamma; P64; SCIDX; SCIDX1; Cytokine receptor common subunit gamma; Gamma C; gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; IL2RG_HUMAN; Interleukin-2 receptor subunit gamma; p64; SCIDX; SCIDX1.
研究領(lǐng)域 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞膜受體
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow,
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
細(xì)胞定位 細(xì)胞膜
性 狀 Lyophilized or Liquid
濃 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-2R gamma
亞 型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-IL-2R gamma/FITC,FITC標(biāo)記的白介素2受體γ鏈抗體產(chǎn)品介紹：Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins.
In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6.
The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement. Mutation of IL2R gamma has been determined to be the cause of severe X-linked combined immunodeficiency (X SCID), a disease that is characterized by the absence of T cells and NK cells.
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IFABP（Intestinal Fatty acid binding protein） 小腸型脂肪酸結(jié)合蛋白抗體
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human IFN-β (Interferon β) 干擾素-β抗體（抗）
human IFN-α (Interferon α ) 干擾素-α抗體（抗）
IFN-α2b(Interferon alpha 2b) 干擾素α2b抗體
IFN-β (Interferon β) 干擾素-β抗體（大鼠、小鼠）
IFN-γ(Human Interferon γ ）Monoclonal antibody 鼠抗干擾素-γ/IFN-gamma單克隆抗體
IFN-gamma(Interferon gamma )(human) 干擾素-γ抗體（抗）
IFN gamma(Interferon gamma)(mouse,rat) 干擾素-γ抗體 （抗大、小鼠）
IFN-γR/CD119（Interferon-γR receptor） 干擾素-γ受體抗體
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IL-10(Interleukin-10) 白介素10抗體
IL-11(Interleukin-11) 白介素11抗體
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IL-13(Interleukin-13) 白介素13抗體
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