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疏水反相保留機(jī)理、硅膠顆粒

詳細(xì)介紹

與CORTECS，CSH和BEH顆粒相比，ACQUITY UPLC HSS色譜柱為極性與非極性分析物提供更理想、更平衡的保留效果。經(jīng)過(guò)工藝優(yōu)化的硅膠顆粒，其機(jī)械強(qiáng)度與穩(wěn)定性更能耐受。UPLC系統(tǒng)操作壓力。5種差異較大的鍵合相，提供更寬泛的選擇空間，除了傳統(tǒng)的疏水反相保留機(jī)理之外，還有偶極-偶極、芳香與氫鍵相互作用。

ACQUITY UPLC HSS C18 SB色譜柱是一種未封端、低覆蓋度硅膠基質(zhì)C18化學(xué)，可為受硅醇基作用影響的化合物提供其它選擇性。HSS C18 SB色譜柱硅醇活性提高，使得堿性化合物的保留更強(qiáng)(由于與殘留硅醇基的次級(jí)作用)，同時(shí)降低了對(duì)非堿性分析物的保留

(由于其低配體密度以及離子推斥性)。該保留特征的組合產(chǎn)生了一種有用的方法開(kāi)發(fā)工具，可為堿性分析物提供不同的選擇性(SB：Selectivity for Bases)，同時(shí)還可保持優(yōu)異峰形。

A rapid and simple LC-MS/MS method was developed and validated for the simultaneous estimation of sofosbuvir (SF) and its metabolite GS-331007 (GS) using famotidine as an internal standard (IS). The Xevo TQD LC-MS/MS was operated under the multiple-reaction monitoring mode using electrospray ionization. Extraction with ethyl acetate was used in sample preparation. The prepared samples were chromatographed on Acquity UPLC HSS C18 (50 mm × 2.1 mm, 1.8 μm) column by pumping 0.1% formic acid and acetonitrile (50:50, v/v) in an isocratic mode at a flow rate of 0.3 ml/min. Method validation was performed as per the FDA guidelines and the standard curves were found to be linear in the range of 10–2500 ng/ml for both SF and its metabolite. The intra-day and inter-day precision and accuracy results were within the acceptable limits. A very short run time of 1.2 min made it possible to analyze more than 300 human plasma samples per day. The developed assay method was successfully applied to a bioequivalence study in human volunteers.

品名	編號(hào)
ACQUITY - Xselect HSS C18 Method Transfer Kit, 100?, 1.8 - 5 µm, 2.1 - 4.6 mm X 50 - 100mm, 2/pkg	186004968
ACQUITY - Xselect HSS C18 Method Transfer Kit, 100?, 1.8 - 5 µm, 2.1 - 4.6 mm X 50 - 150mm, 2/pkg	186004961
ACQUITY - Xselect HSS C18 SB Method Transfer Kit, 100?, 1.8 - 3.5 µm, 2.1 - 4.6 mm X 50 - 100mm, 2...	186004970
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 1 mm X 100 mm, 1/pkg	186003530
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 1 mm X 150 mm, 1/pkg	186003531
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 3 mm X 30 mm, 3/pkg	176001817
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 3 mm X 50 mm, 3/pkg	176001818
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 3 mm X 100 mm, 3/pkg	176001819
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 1 mm X 50 mm, 3/pkg	176001121
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 2.1 mm X 30 mm, 3/pkg	176001398
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 2.1 mm X 150 mm, 3/pkg	176001126
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 1 mm X 100 mm, 3/pkg	176001122
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 1 mm X 150 mm, 3/pkg	176001123
ACQUITY UPLC HSS C18 Method Validation Kit, 100?, 1.8 µm, 2.1 mm X 150 mm, 3/pkg	186006026
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 2.1 mm X 50 mm, 3/pkg	176001124
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 2.1 mm X 100 mm, 3/pkg	176001125
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 2.1 mm X 150 mm, 1/pkg	186003534
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 2.1 mm X 100 mm, 1/pkg	186003533
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 2.1 mm X 30 mm, 1/pkg	186003987
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 2.1 mm X 50 mm, 1/pkg	186003532
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 3 mm X 30 mm, 1/pkg	186004682
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 3 mm X 50 mm, 1/pkg	186004683
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 3 mm X 100 mm, 1/pkg	186004684
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 3 mm X 150 mm, 1/pkg	186004685
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 3 mm X 75 mm, 1/pkg	186005618
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 2.1 mm X 75 mm, 1/pkg	186005615
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 3 mm X 150 mm, 3/pkg	176001820
ACQUITY UPLC HSS C18 Column, 100?, 1.8 µm, 1 mm X 50 mm, 1/pkg	186003529
ACQUITY UPLC HSS C18 VanGuard Pre-column, 100?, 1.8 µm, 2.1 mm X 5 mm, 3/pkg	186003981
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 3 mm X 150 mm, 1/pkg	186004689
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 2.1 mm X 30 mm, 3/pkg	176001559
ACQUITY UPLC HSS C18 Method Validation Kit, 100?, 1.8 µm, 2.1 mm X 50 mm, 3/pkg	186004057
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 1 mm X 50 mm, 3/pkg	176001556
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 1 mm X 100 mm, 3/pkg	176001557
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 1 mm X 150 mm, 3/pkg	176001558
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 3 mm X 100 mm, 1/pkg	186004826
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 2.1 mm X 100 mm, 1/pkg	186004119
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 2.1 mm X 30 mm, 1/pkg	186004117
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 2.1 mm X 50 mm, 1/pkg	186004118
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 1 mm X 100 mm, 1/pkg	186004115
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 1 mm X 150 mm, 1/pkg	186004116
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 3 mm X 30 mm, 1/pkg	186004686
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 3 mm X 100 mm, 3/pkg	176001823
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 2.1 mm X 75 mm, 1/pkg	186005616
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 3 mm X 150 mm, 3/pkg	176001824
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 2.1 mm X 150 mm, 1/pkg	186004120
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 3 mm X 30 mm, 3/pkg	176001821
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 2.1 mm X 150 mm, 3/pkg	176001562
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 2.1 mm X 100 mm, 3/pkg	176001561
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 2.1 mm X 50 mm, 3/pkg	176001560
ACQUITY UPLC HSS C18 Method Validation Kit, 100?, 1.8 µm, 3 mm X 100 mm, 3/pkg	186004704
ACQUITY UPLC HSS C18 Method Validation Kit, 100?, 1.8 µm, 3 mm X 50 mm, 3/pkg	186004703
ACQUITY UPLC HSS C18 SB VanGuard Pre-column, 100?, 1.8 µm, 2.1 mm X 5 mm, 3/pkg	186004136
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100?, 1.8 µm, 2.1 mm X 150 mm, 3/pkg	186006027
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100?, 1.8 µm, 2.1 mm X 50 mm, 3/pkg	186004137
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100?, 1.8 µm, 2.1 mm X 100 mm, 3/pkg	186004138
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 3 mm X 50 mm, 3/pkg	176001822
ACQUITY UPLC HSS C18 SB Column, 100?, 1.8 µm, 3 mm X 75 mm, 1/pkg	186005619
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100?, 1.8 µm, 3 mm X 50 mm, 3/pkg	186004705
ACQUITY UPLC HSS C18 SB Method Validation Kit, 100?, 1.8 µm, 3 mm X 100 mm, 3/pkg	186004709