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三磷酸腺苷結(jié)合轉(zhuǎn)運蛋白G超家族成員5抗體現(xiàn)貨供應(yīng)，產(chǎn)品價格洽談，公司提供完整的，提供*的售前售后服務(wù)！
英文名稱 ABCG5
中文名稱 三磷酸腺苷結(jié)合轉(zhuǎn)運蛋白G超家族成員5抗體
別    名 ABCG5; ABCG5_HUMAN; ATP binding cassette sub family G (WHITE) member 5 (sterolin 1); ATP binding cassette sub family G member 5; ATP-binding cassette sub-family G member 5; Sterolin 1; Sterolin-1; STSL.
三磷酸腺苷結(jié)合轉(zhuǎn)運蛋白G超家族成員5抗體
研究領(lǐng)域腫瘤  細胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  轉(zhuǎn)運蛋白  結(jié)合蛋白
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量 72kDa
細胞定位細胞膜
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免疫原 KLH conjugated synthetic peptide derived from human ABCG5
亞    型 IgG
純化方法 affinity purified by Protein A
儲存液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
三磷酸腺苷結(jié)合轉(zhuǎn)運蛋白G超家族成員5抗體
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008].

Function:
Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

Subunit:
May form heterodimers with ABCG8 or be tightly coupled to ABCG8 along a pathway regulating diatery-sterol absorption and excretion.

Subcellular Location:
Membrane; Multi-pass membrane protein (Probable).

Tissue Specificity:
Strongly expressed in the liver, lower levels in the small intestine and colon.

DISEASE:
Defects in ABCG5 are a cause of sitosterolemia (STSL) [MIM:210250]; also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease.

Similarity:
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Contains 1 ABC transmembrane type-2 domain.
Contains 1 ABC transporter domain.

Database links: